Frederick Sanger

One of only two people to win the Nobel Prize in Chemistry twice -- in 1958 for determining the structure of insulin via protein sequencing, and in 1980 for developing a method to sequence nucleic acids -- two distinct methodological breakthroughs decades apart.

Spent his entire academic career at Cambridge focused on sequencing methodology specifically, rather than a broader or more varied research agenda, sustaining that focus across both breakthroughs.

After already achieving the field's highest recognition for protein sequencing, moved into the substantially different technical domain of nucleic-acid sequencing -- described by colleagues and biographical accounts as personally reserved and non-self-promoting even as this second body of work also won a Nobel Prize.

Choosing to move into a new technical domain after already reaching the top of his field, rather than remaining in established territory, is the basis for the profile's curiosity score. Curiosity